Revolutionizing how we fight antibiotic resistant bacteria

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1928D

1928D is an online platform that provides you with a powerful bioinformatic analysis of your whole genome sequencing data enabling decision support for infectious diseases.

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All-in-one

1928D offers an all-in-one Software-as-a-Service delivering:

  • Prediction of antibiotic resistance
  • Identification of virulence factors
  • Typing and identification of outbreaks
A screen shot in the 1928D platform, showing the sample index view with a table containing all samples and information about them.
A screen shot in the 1928D platform, showing the page where you can selecet and upload samples and see the progress of the upload.

Easy-to-use

The analysis runs with minimized hands-on effort and there is a strong focus on simplified and efficient result visualization for non-specialized users.

Version 1.0

The first version focuses on Staphylococcus aureus which is one of the most common pathogens in the hospital setting. When resistant to methicillin it is commonly called MRSA, which is a bacteria conferring serious infections and extensive problems for patients worldwide.

Up-to-date

We are continuously updating the databases and extending the scope of the service by expanding software functionality and species coverage.

How does it work?

1928D analyzes raw data from whole genome sequencing machines and matches the processed data to the proprietary databases that have been manually curated containing only clinically relevant genetic markers. The result in the form of a resistance and typing profile is delivered to the client in minutes.

Upload

Raw data generated by a sequencing machine is uploaded to our cloud based web-service.

Data analyzed

The data is analyzed and matched against our database of resistance and typing patterns.

Results

The result is delivered back and can be used as a decision support for antibiotic treatment of the infected patient.

Antibiotic Resistance

How antibiotic resistance occurs in five stages.
                      First stage: We have a population of bacteria.
                      Second stage: During division some bacteria undergoes a mutation in its DNA resulting in an antibiotic resistance.
                      Third stage: Antibiotic is added and kills all sensitive bacteria.
                      Fourth stage: Only resistant bacteria have survived.
                      Fifth stage: The resistant bacteria now divides and forms a population.

Antibiotic resistance is one of the most serious threats to human health in modern times. The world is about to enter a post antibiotic era where minor infections will be lethal. Better diagnostic methods are needed to treat patients more efficiently and diminish the spread of antibiotic resistant bacteria.

MRSA

Percentage of tested Staphylococcus aureus isolates that are methicillin resistant (MRSA), by country, 2011-2014

A world map showing the percentage of tested Staphylococcus aureus isolates that are
                          methicillin resistant (MRSA), by country, in 2011-2014. Mauritania, the west coast of
                          South America and Russia all have very high resistance rates of 70-100%. Canada, most
                          parts of Europe and Australia have the lowest values of 0-19%. The US, India and China
                          for example are somewhere between, with a resistance of 40-59% and 20-39% respectively.
                          There is no data for most countries in Africa (only data from five african countries)
                          as well as some countries in eastern South America and some parts of western Asia. A legend which pairs the colors in the map to percentages.
                          Including the intervals: 0-19%, 20-39%, 40-59%, 60-79%, 80-100% and No data.
Source: CDDEP 2015, WHO 2014, and PAHO.

Why are we the best at solving this?

By being a front-runner in the technical development of personalized medicine, we have a unique position of addressing the global challenge of antibiotic resistance.

We are hiring

Do you want to participate in the fight against antibiotic resistant bacteria? Join our dynamic development team and make a difference!

Click here to go to the jobs page.