Identifying and characterizing pathogens

WGS sample characterization

Whole Genome Sequencing (WGS) of cultured isolates is used in microbiology for several purposes:

  1. Microbial Identification: WGS precisely identifies microorganisms, including novel strains.

  2. Strain Typing: It differentiates between strains of the same species, helping track outbreaks and genetic diversity.

  3. Antibiotic Resistance Profiling: WGS identifies resistance genes and monitor resistance trends.

  4. Virulence Factor Identification: It reveals genes responsible for pathogenicity, aiding in understanding how microbes cause disease.

  5. Tracking Transmission and Evolution: WGS traces the spread of pathogens and tracks genetic changes over time.

  6. Phylogenetic Analysis: It helps construct phylogenetic trees to study the evolutionary relationships between strains.

  7. Metabolic Pathway Analysis: WGS provides insights into how microbes metabolize nutrients and survive in different environments.

Analysis includes:

  • Quality control including sample quality

  • Automatic species identification

  • Strain typing

  • Antimicrobial resistance and virulence

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